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Three serendipitous pathways in E. coli can bypass a block in pyridoxal-5′-phosphate synthesis

Bacterial genomes encode hundreds to thousands of enzymes, most of which are specialized for particular functions. However, most enzymes have inefficient promiscuous activities, as well, that generally serve no purpose. Promiscuous reactions can be patched together to form multistep metabolic pathwa...

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Autors principals: Kim, Juhan, Kershner, Jamie P, Novikov, Yehor, Shoemaker, Richard K, Copley, Shelley D
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010111/
https://ncbi.nlm.nih.gov/pubmed/21119630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2010.88
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