Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity

Runx2 is indispensable for osteoblast lineage commitment and early differentiation but also blocks osteoblast maturation, thereby causing bone loss in Runx2 transgenic mice. Zinc finger protein 521 (Zfp521) antagonizes Runx2 in vivo. Eliminating one Zfp521 allele mitigates the cleidocranial dysplasi...

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Bibliografiset tiedot
Päätekijät: Hesse, Eric, Saito, Hiroaki, Kiviranta, Riku, Correa, Diego, Yamana, Kei, Neff, Lynn, Toben, Daniel, Duda, Georg, Atfi, Azeddine, Geoffroy, Valérie, Horne, William C., Baron, Roland
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Rockefeller University Press 2010
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Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010073/
https://ncbi.nlm.nih.gov/pubmed/21173110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201009107
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