Distinct Modes of Inhibition by Sclerostin on Bone Morphogenetic Protein and Wnt Signaling Pathways

Sclerostin is expressed by osteocytes and has catabolic effects on bone. It has been shown to antagonize bone morphogenetic protein (BMP) and/or Wnt activity, although at present the underlying mechanisms are unclear. Consistent with previous findings, Sclerostin opposed direct Wnt3a-induced but not...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Krause, Carola, Korchynskyi, Olexandr, de Rooij, Karien, Weidauer, Stella E., de Gorter, David J. J., van Bezooijen, Rutger L., Hatsell, Sarah, Economides, Aris N., Mueller, Thomas D., Löwik, Clemens W. G. M., ten Dijke, Peter
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2010
विषय:
Signal Transduction
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009889/
https://ncbi.nlm.nih.gov/pubmed/20952383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.153890
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