Distinct Modes of Inhibition by Sclerostin on Bone Morphogenetic Protein and Wnt Signaling Pathways

Sclerostin is expressed by osteocytes and has catabolic effects on bone. It has been shown to antagonize bone morphogenetic protein (BMP) and/or Wnt activity, although at present the underlying mechanisms are unclear. Consistent with previous findings, Sclerostin opposed direct Wnt3a-induced but not...

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Главные авторы: Krause, Carola, Korchynskyi, Olexandr, de Rooij, Karien, Weidauer, Stella E., de Gorter, David J. J., van Bezooijen, Rutger L., Hatsell, Sarah, Economides, Aris N., Mueller, Thomas D., Löwik, Clemens W. G. M., ten Dijke, Peter
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2010
Предметы:
Signal Transduction
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009889/
https://ncbi.nlm.nih.gov/pubmed/20952383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.153890
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