Brain-specific Phgdh Deletion Reveals a Pivotal Role for l-Serine Biosynthesis in Controlling the Level of d-Serine, an N-methyl-d-aspartate Receptor Co-agonist, in Adult Brain

In mammalian brain, d-serine is synthesized from l-serine by serine racemase, and it functions as an obligatory co-agonist at the glycine modulatory site of N-methyl-d-aspartate (NMDA)-selective glutamate receptors. Although diminution in d-serine level has been implicated in NMDA receptor hypofunct...

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Main Authors: Yang, Jung Hoon, Wada, Akira, Yoshida, Kazuyuki, Miyoshi, Yurika, Sayano, Tomoko, Esaki, Kayoko, Kinoshita, Masami O., Tomonaga, Shozo, Azuma, Norihiro, Watanabe, Masahiko, Hamase, Kenji, Zaitsu, Kiyoshi, Machida, Takeo, Messing, Albee, Itohara, Shigeyoshi, Hirabayashi, Yoshio, Furuya, Shigeki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009864/
https://ncbi.nlm.nih.gov/pubmed/20966073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.187443
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