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A naturally chimeric type IIA topoisomerase in Aquifex aeolicus highlights an evolutionary path for the emergence of functional paralogs

Bacteria frequently possess two type IIA DNA topoisomerases, gyrase and topo IV, which maintain chromosome topology by variously supercoiling, relaxing, and disentangling DNA. DNA recognition and functional output is thought to be controlled by the C-terminal domain (CTD) of the topoisomerase DNA bi...

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Detalhes bibliográficos
Main Authors: Tretter, Elsa M., Lerman, Jeffrey C., Berger, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009783/
https://ncbi.nlm.nih.gov/pubmed/21076033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012938107
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