Reactivating aberrantly hypermethylated p15 gene in leukemic T cells by a phenylhexyl isothiocyanate mediated inter-active mechanism on DNA and chromatin

BACKGROUND: We have previously demonstrated that phenylhexyl isothiocyanate (PHI), a synthetic isothiocyanate, inhibits histone deacetylases and remodels chromatins to induce growth arrest in HL-60 myeloid leukemia cells in a concentration-dependent manner. METHODS: To investigate the effect of PHI,...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Jiang, Shaohong, Ma, Xudong, Huang, Yiqun, Xu, Yunlu, Zheng, Ruiji, Chiao, Jen-Wei
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2010
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009608/
https://ncbi.nlm.nih.gov/pubmed/21114827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-3-48
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares