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Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence?
Stem/progenitor cells ensure tissue and organism homeostasis and might represent a frequent target of transformation. Although these cells are potentially immortal, their life span is restrained by signaling pathways (p19-p53; p16-Rb) that are activated by DNA damage (telomere dysfunction, environme...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC300887/ https://ncbi.nlm.nih.gov/pubmed/14702099 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420750 |
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