A Novel HMM-Based Method for Detecting Enriched Transcription Factor Binding Sites Reveals RUNX3 as a Potential Target in Pancreatic Cancer Biology

BACKGROUND: Pancreatic adenocarcinoma (PAC) is one of the most intractable malignancies. In order to search for potential new therapeutic targets, we relied on computational methods aimed at identifying transcription factor binding sites (TFBSs) over-represented in the promoter regions of genes diff...

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Detaylı Bibliyografya
Asıl Yazarlar: Levkovitz, Liron, Yosef, Nir, Gershengorn, Marvin C., Ruppin, Eytan, Sharan, Roded, Oron, Yoram
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2010
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3008686/
https://ncbi.nlm.nih.gov/pubmed/21203558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014423
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