Identification of a low-risk subgroup of HER-2-positive breast cancer by the 70-gene prognosis signature

BACKGROUND: Overexpression of HER-2 is observed in 15–25% of breast cancers, and is associated with increased risk of recurrence. Current guidelines recommend trastuzumab and chemotherapy for most HER-2-positive patients. However, the majority of patients does not recur and might thus be overtreated...

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Hlavní autoři: Knauer, M, Cardoso, F, Wesseling, J, Bedard, P L, Linn, S C, Rutgers, E J T, van 't Veer, L J
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2010
Témata:
Clinical Study
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3008599/
https://ncbi.nlm.nih.gov/pubmed/21081926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605916
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