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DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal
The molecular controls that govern the differentiation of embryonic stem (ES) cells remain poorly understood. DGCR8 is an RNA-binding protein that assists the RNase III enzyme Drosha in the processing of microRNAs (miRNAs), a subclass of small RNAs. Here we study the role of miRNAs in ES cell differ...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3008549/ https://ncbi.nlm.nih.gov/pubmed/17259983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng1969 |
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