Spontaneous abrogation of the G(2) DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients

DNA damage checkpoints in the cell cycle may be important barriers against cancer progression in human cells. Fanconi anemia (FA) is an inherited DNA instability disorder that is associated with bone marrow failure and a strong predisposition to cancer. Although FA cells experience constitutive chro...

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Главные авторы: Ceccaldi, Raphael, Briot, Delphine, Larghero, Jérôme, Vasquez, Nadia, Dubois d’Enghien, Catherine, Chamousset, Delphine, Noguera, Maria-Elena, Waisfisz, Quinten, Hermine, Olivier, Pondarre, Corinne, Leblanc, Thierry, Gluckman, Eliane, Joenje, Hans, Stoppa-Lyonnet, Dominique, Socié, Gérard, Soulier, Jean
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2010
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3007150/
https://ncbi.nlm.nih.gov/pubmed/21183791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43836
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