Onset of autoimmune lymphoproliferative syndrome (ALPS) in humans as a consequence of genetic defect accumulation

Autoimmune diseases develop in approximately 5% of humans. They can arise when self-tolerance checkpoints of the immune system are bypassed as a consequence of inherited mutations of key genes involved in lymphocyte activation, survival, or death. For example, autoimmune lymphoproliferative syndrome...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Magerus-Chatinet, Aude, Neven, Bénédicte, Stolzenberg, Marie-Claude, Daussy, Cécile, Arkwright, Peter D., Lanzarotti, Nina, Schaffner, Catherine, Cluet-Dennetiere, Sophie, Haerynck, Filomeen, Michel, Gérard, Bole-Feysot, Christine, Zarhrate, Mohammed, Radford-Weiss, Isabelle, Romana, Serge P., Picard, Capucine, Fischer, Alain, Rieux-Laucat, Frédéric
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Clinical Investigation 2010
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3007148/
https://ncbi.nlm.nih.gov/pubmed/21183795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43752
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