XPC silencing in normal human keratinocytes triggers metabolic alterations that drive the formation of squamous cell carcinomas

DNA damage is a well-known initiator of tumorigenesis. Studies have shown that most cancer cells rely on aerobic glycolysis for their bioenergetics. We sought to identify a molecular link between genomic mutations and metabolic alterations in neoplastic transformation. We took advantage of the intri...

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Detalhes bibliográficos
Main Authors: Rezvani, Hamid Reza, Kim, Arianna L., Rossignol, Rodrigue, Ali, Nsrein, Daly, Meaghan, Mahfouf, Walid, Bellance, Nadège, Taïeb, Alain, de Verneuil, Hubert, Mazurier, Frédéric, Bickers, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3007130/
https://ncbi.nlm.nih.gov/pubmed/21123941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40087
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