Reactive oxygen species-mediated apoptosis contributes to chemosensitization effect of saikosaponins on cisplatin-induced cytotoxicity in cancer cells

BACKGROUND: Saikosaponin-a and -d, two naturally occurring compounds derived from Bupleurum radix, have been shown to exert anti-cancer activity in several cancer cell lines. However, the effect of combination of saikosaponins with chemotherapeutic drugs has never been addressed. Thus, we investigat...

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Detalhes bibliográficos
Main Authors: Wang, Qiong, Zheng, Xue-lian, Yang, Lan, Shi, Fang, Gao, Lin-bo, Zhong, Ying-jia, Sun, Hong, He, Fan, Lin, Yong, Wang, Xia
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3006358/
https://ncbi.nlm.nih.gov/pubmed/21143894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-29-159
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