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In silico experiments of single-chain antibody fragment against drugs of abuse
Three sets of in silico experiments have been conducted to elucidate the binding mechanics of two drugs, (+)-methamphetamine (METH) and amphetamine (AMP) to the single-chain variable fragment (scFv) recently engineered from anti-METH monoclonal antibody mAb6H4 (IgG, κ light chain, K(d) = 11nM). The...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3006299/ https://ncbi.nlm.nih.gov/pubmed/21056529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2010.10.008 |
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