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Testing SNPs and sets of SNPs for importance in association studies

A major goal of genetic association studies concerned with single nucleotide polymorphisms (SNPs) is the detection of SNPs exhibiting an impact on the risk of developing a disease. Typically, this problem is approached by testing each of the SNPs individually. This, however, can lead to an inaccurat...

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Bibliographic Details
Main Authors: Schwender, Holger, Ruczinski, Ingo, Ickstadt, Katja
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3006123/
https://ncbi.nlm.nih.gov/pubmed/20601626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxq042
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