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The influence of metoprolol dosage release formulation on the pharmacokinetic drug interaction with paroxetine

Studies have demonstrated an influence of dosage release formulations on drug interactions and enantiomeric plasma concentrations. Metoprolol is a commonly used β-adrenergic antagonist metabolized by CYP2D6. The CYP2D6 inhibitor paroxetine has previously been shown to interact with metoprolol tartra...

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Hlavní autoři: Stout, Stephen M., Nielsen, Jace, Welage, Lynda S., Shea, Michael, Brook, Robert, Kerber, Kevin, Bleske, Barry E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3006004/
https://ncbi.nlm.nih.gov/pubmed/20400652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0091270010365559
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