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Calpain inhibitors reduce retinal hypoxia in ischemic retinopathy by improving neovascular architecture and functional perfusion

In ischemic retinopathies, underlying hypoxia drives abnormal neovascularization that damages retina and causes blindness. The abnormal neovasculature is tortuous and leaky and fails to alleviate hypoxia, resulting in more pathological neovascularization and retinal damage. With an established model...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hoang, Mien V., Smith, Lois E. H., Senger, Donald R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005970/
https://ncbi.nlm.nih.gov/pubmed/20804843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2010.08.008
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