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The Opdc missense mutation of Pax2 has a milder than loss-of-function phenotype

Renal-coloboma syndrome, also known as papillorenal syndrome, is an autosomal dominant human disorder in which optic disc coloboma is associated with kidney abnormalities. Mutations in the paired domain transcription factor PAX2 have been found to be the underlying cause of this disease. Disease sev...

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Main Authors: Cross, Sally H., McKie, Lisa, West, Katrine, Coghill, Emma L., Favor, Jack, Bhattacharya, Shoumo, Brown, Steve D.M., Jackson, Ian J.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005898/
https://ncbi.nlm.nih.gov/pubmed/20943750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq457
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