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Solvent-induced lid opening in lipases: A molecular dynamics study
In most lipases, a mobile lid covers the substrate binding site. In this closed structure, the lipase is assumed to be inactive. Upon activation of the lipase by contact with a hydrophobic solvent or at a hydrophobic interface, the lid opens. In its open structure, the substrate binding site is acce...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Wiley Subscription Services, Inc., A Wiley Company
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3005783/ https://ncbi.nlm.nih.gov/pubmed/20812327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.493 |
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