Fibroblast Growth Factor Receptor Signaling Dramatically Accelerates Tumorigenesis and Enhances Oncoprotein Translation in the Mouse Mammary Tumor Virus–Wnt-1 Mouse Model of Breast Cancer

Fibroblast growth factor (FGF) cooperates with the Wnt/β-catenin pathway to promote mammary tumorigenesis. To investigate the mechanisms involved in FGF/Wnt cooperation, we genetically engineered a model of inducible FGF receptor (iFGFR) signaling in the context of the well-established mouse mammary...

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Detalhes bibliográficos
Main Authors: Pond, Adam C., Herschkowitz, Jason I., Schwertfeger, Kathryn L., Welm, Bryan, Zhang, Yiqun, York, Brian, Cardiff, Robert D., Hilsenbeck, Susan, Perou, Charles M., Creighton, Chad J., Lloyd, Richard E., Rosen, Jeffrey M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005245/
https://ncbi.nlm.nih.gov/pubmed/20501844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4404
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