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Hdac3 is essential for the maintenance of chromatin structure and genome stability

Hdac3 is essential for efficient DNA replication and DNA damage control. Deletion of Hdac3 impaired DNA repair and greatly reduced chromatin compaction and heterochromatin content. These defects corresponded to increases in histone H3K9,K14ac, and H4K5ac and H4K12ac in late S phase of the cell cycle...

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التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Bhaskara, Srividya, Knutson, Sarah K., Jiang, Guochun, Chandrasekharan, Mahesh B., Wilson, Andrew J., Zheng, Siyuan, Yenamandra, Ashwini, Locke, Kimberly, Yuan, Jia-ling, Bonine-Summers, Alyssa R., Wells, Christina E., Kaiser, Jonathan F., Washington, M. Kay, Zhao, Zhongming, Wagner, Florence F., Sun, Zu-Wen, Xia, Fen, Holson, Edward B., Khabele, Dineo, Hiebert, Scott W.
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	2010
الموضوعات:	Article
الوصول للمادة أونلاين:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3004468/ https://ncbi.nlm.nih.gov/pubmed/21075309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.10.022
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Hdac3 is essential for the maintenance of chromatin structure and genome stability

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