Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma

When it escapes early detection, malignant melanoma becomes a highly-lethal and treatment-refractory cancer. Melastatin is greatly downregulated in metastatic melanomas and is widely believed to function as a melanoma tumor suppressor. Here we report that tumor suppressive activity is not mediated b...

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Bibliografiske detaljer
Main Authors: Levy, Carmit, Khaled, Mehdi, Iliopoulos, Dimitrios, Janas, Maja M., Schubert, Steffen, Pinner, Sophie, Chen, Po-Hao, Li, Shuqiang, Fletcher, Anne, Yokoyama, Satoru, Scott, Kenneth L., Garraway, Levi A., Song, Jun S., Granter, Scott R., Turley, Shannon J., Fisher, David E., Novina, Carl D.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3004467/
https://ncbi.nlm.nih.gov/pubmed/21109473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.11.020
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