Tetrameric Ring Formation of Epstein-Barr Virus Polymerase Processivity Factor Is Crucial for Viral Replication

The Epstein-Barr virus BMRF1 DNA polymerase processivity factor, which is essential for viral genome replication, exists mainly as a C-shaped head-to-head homodimer but partly forms a ring-shaped tetramer through tail-to-tail association. Based on its molecular structure, several BMRF1 mutant viruse...

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Bibliographic Details
Main Authors: Nakayama, Sanae, Murata, Takayuki, Yasui, Yoshihiro, Murayama, Kazutaka, Isomura, Hiroki, Kanda, Teru, Tsurumi, Tatsuya
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3004297/
https://ncbi.nlm.nih.gov/pubmed/20926567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01394-10
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