TRAIL-induced caspase/p38 activation is responsible for the increased catalytic and invasive activities of Akt

We previously observed that TRAIL induces acquired TRAIL resistance coinciding with increased Akt phosphorylation brought about by the Src-PI3K-Akt signaling pathways and mediated by c-Cbl. c-Cbl, a ubiquitously expressed cytoplasmic adaptor protein, is simultaneously involved in the rapid degradati...

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Main Authors: SUN, BO K., KIM, JOO-HANG, NGUYEN, HOAN N., KIM, SO Y., OH, SEEUN, LEE, YONG J., SONG, JAE J.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3004145/
https://ncbi.nlm.nih.gov/pubmed/21109947
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