Targeted Deletion of the Extracellular Signal-Regulated Protein Kinase 5 Attenuates Hypertrophic Response, and Promotes Pressure Overload-Induced Apoptosis in the Heart

RATIONALE: Mitogen-activated protein kinase (MAPK) pathways provide a critical connection between extrinsic and intrinsic signals to cardiac hypertrophy. Extracellular signal-regulated protein kinase 5 (ERK5), an atypical MAP kinase is activated in the heart by pressure overload. However, the role o...

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Main Authors: Kimura, Tomomi E., Jin, Jiawei, Zi, Min, Prehar, Sukhpal, Liu, Wei, Oceandy, Delvac, Abe, Jun-ichi, Neyses, Ludwig, Weston, Arthur H., Cartwright, Elizabeth J., Wang, Xin
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003662/
https://ncbi.nlm.nih.gov/pubmed/20075332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.209320
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