DNA polymeraseη protein expression predicts treatment response and survival of metastatic gastric adenocarcinoma patients treated with oxaliplatin-based chemotherapy

BACKGROUND: DNA polymerase η (pol η) is capable of bypassing DNA adducts produced by cisplatin or oxaliplatin and is associated with cellular tolerance to platinum. Previous studies showed that defective pol η resulted in enhanced cisplatin or oxaliplatin sensitivity in some cell lines. The purpose...

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Hoofdauteurs: Teng, Kai-yuan, Qiu, Miao-zhen, Li, Zhuang-hua, Luo, Hui-yan, Zeng, Zhao-lei, Luo, Rong-zhen, Zhang, Hui-zhong, Wang, Zhi-qiang, Li, Yu-hong, Xu, Rui-hua
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2010
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003639/
https://ncbi.nlm.nih.gov/pubmed/21110884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-8-126
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