Silencing of CDK5 Reduces Neurofibrillary Tangles in Transgenic Alzheimer's Mice

Alzheimer's disease is a major cause of dementia for which treatments remain unsatisfactory. Cyclin-dependent kinase 5 (CDK5) is a relevant kinase that has been hypothesized to contribute to the tau pathology. Several classes of chemical inhibitors for CDK5 have been developed, but they general...

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Autores principales: Piedrahita, Diego, Hernández, Israel, López-Tobón, Alejandro, Fedorov, Dmitry, Obara, Boguslaw, Manjunath, B. S., Boudreau, Ryan L., Davidson, Beverly, LaFerla, Frank, Gallego-Gómez, Juan Carlos, Kosik, Kenneth S., Cardona-Gómez, Gloria Patricia
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2010
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003593/
https://ncbi.nlm.nih.gov/pubmed/20962218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3637-10.2010
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