Tomosyn Inhibits Synaptotagmin-1-mediated Step of Ca(2+)-dependent Neurotransmitter Release through Its N-terminal WD40 Repeats

Neurotransmitter release is triggered by Ca(2+) binding to a low affinity Ca(2+) sensor, mostly synaptotagmin-1, which catalyzes SNARE-mediated synaptic vesicle fusion. Tomosyn negatively regulates Ca(2+)-dependent neurotransmitter release by sequestering target SNAREs through the C-terminal VAMP-li...

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Main Authors: Yamamoto, Yasunori, Mochida, Sumiko, Miyazaki, Naoyuki, Kawai, Katsuhisa, Fujikura, Kohei, Kurooka, Takao, Iwasaki, Kenji, Sakisaka, Toshiaki
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003394/
https://ncbi.nlm.nih.gov/pubmed/20978127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.156893
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