Grainyhead-like 2 Enhances the Human Telomerase Reverse Transcriptase Gene Expression by Inhibiting DNA Methylation at the 5′-CpG Island in Normal Human Keratinocytes

We recently identified Grainyhead-like 2 (GRHL2) as a novel transcription factor that binds to and regulates the activity of the human telomerase reverse transcriptase (hTERT) gene promoter. In this study, we investigated the biological functions of GRHL2 and the molecular mechanism underlying hTERT...

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Main Authors: Chen, Wei, Dong, Qinghua, Shin, Ki-Hyuk, Kim, Reuben H., Oh, Ju-Eun, Park, No-Hee, Kang, Mo K.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Gene Regulation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003386/
https://ncbi.nlm.nih.gov/pubmed/20938050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.103812
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