Feed-forward Signaling by Membrane-bound Ligand Receptor Circuit: THE CASE OF NOTCH DELTA-LIKE 4 LIGAND IN ENDOTHELIAL CELLS

The DELTA like-4 ligand (DLL4) belongs to the highly conserved NOTCH family and is specifically expressed in the endothelium. DLL4 regulates crucial processes in vascular growth, including endothelial cell (EC) sprouting and arterial specification. Its expression is increased by VEGF-A. In the prese...

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Detalhes bibliográficos
Main Authors: Caolo, Vincenza, van den Akker, Nynke M. S., Verbruggen, Sanne, Donners, Marjo M. P. C., Swennen, Geertje, Schulten, Henny, Waltenberger, Johannes, Post, Mark J., Molin, Daniel G. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003367/
https://ncbi.nlm.nih.gov/pubmed/20959466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.176065
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