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Crystal Structure of Cardiac-specific Histone Methyltransferase SmyD1 Reveals Unusual Active Site Architecture

SmyD1 is a cardiac- and muscle-specific histone methyltransferase that methylates histone H3 at lysine 4 and regulates gene transcription in early heart development. The unique domain structure characterized by a “split” SET domain, a conserved MYND zinc finger, and a novel C-terminal domain (CTD) d...

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Bibliografiske detaljer
Main Authors: Sirinupong, Nualpun, Brunzelle, Joseph, Ye, Jun, Pirzada, Ali, Nico, Lindsey, Yang, Zhe
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003362/
https://ncbi.nlm.nih.gov/pubmed/20943667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.168187
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