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Crystal Structure of Cardiac-specific Histone Methyltransferase SmyD1 Reveals Unusual Active Site Architecture
SmyD1 is a cardiac- and muscle-specific histone methyltransferase that methylates histone H3 at lysine 4 and regulates gene transcription in early heart development. The unique domain structure characterized by a “split” SET domain, a conserved MYND zinc finger, and a novel C-terminal domain (CTD) d...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3003362/ https://ncbi.nlm.nih.gov/pubmed/20943667 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.168187 |
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