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Structural identification of cation binding pockets in the plasma membrane proton pump

The activity of P-type plasma membrane H(+)-ATPases is modulated by H(+) and cations, with K(+) and Ca(2+) being of physiological relevance. Using X-ray crystallography, we have located the binding site for Rb(+) as a K(+) congener, and for Tb(3+) and Ho(3+) as Ca(2+) congeners. Rb(+) is found coord...

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Detalhes bibliográficos
Main Authors: Ekberg, Kira, Pedersen, Bjørn P., Sørensen, Danny M., Nielsen, Ann K., Veierskov, Bjarke, Nissen, Poul, Palmgren, Michael G., Buch-Pedersen, Morten J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003096/
https://ncbi.nlm.nih.gov/pubmed/21098259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1010416107
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