A Novel, Selective and Efficacious Nanomolar Pyridopyrazinone Inhibitor of (V600E)BRAF

Oncogenic BRAF is a critical driver of proliferation and survival and is thus a validated therapeutic target in cancer. We have developed a potent inhibitor, termed 1t (CCT239065), of the mutant protein kinase, (V600E)BRAF. 1t inhibits signaling downstream of (V600E)BRAF in cancer cells, blocking DN...

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Bibliografiske detaljer
Main Authors: Whittaker, Steven, Ménard, Delphine, Kirk, Ruth, Ogilvie, Lesley, Hedley, Douglas, Zambon, Alfonso, Lopes, Filipa, Preece, Natasha, Manne, Helen, Rana, Sareena, Lambros, Maryou, Reis-Filho, Jorge S, Marais, Richard, Springer, Caroline J
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001191/
https://ncbi.nlm.nih.gov/pubmed/20807807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1366
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