Peptidylarginine Deiminase 2 Suppresses Inhibitory κB Kinase Activity in Lipopolysaccharide-stimulated RAW 264.7 Macrophages

Peptidylarginine deiminases (PADs) are enzymes that convert arginine to citrulline in proteins. In this study, we examined PAD-mediated citrullination and its effect on pro-inflammatory activity in the macrophage cell line RAW 264.7. Citrullination of 45–65-kDa proteins was induced when cells were t...

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Bibliographic Details
Main Authors: Lee, Hye Jeong, Joo, Myungsoo, Abdolrasulnia, Rasul, Young, David G., Choi, Inyeong, Ware, Lorraine B., Blackwell, Timothy S., Christman, Brian W.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000946/
https://ncbi.nlm.nih.gov/pubmed/20937835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.170290
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