Sensing muscle ischemia: coincident detection of acid and ATP via interplay of two ion channels

Ischemic pain – examples include the chest pain of a heart attack and the leg pain of a 30 second sprint – occurs when muscle gets too little oxygen for its metabolic need. Lactic acid cannot act alone to trigger ischemic pain because the pH change is so small. Here we show that another compound rel...

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Detalhes bibliográficos
Main Authors: Birdsong, William T., Fierro, Leonardo, Williams, Frank G., Spelta, Valeria, Naves, Ligia A., Knowles, Michelle, Marsh-Haffner, Josephine, Adelman, John P., Almers, Wolfhard, Elde, Robert P., McCleskey, Edwin W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000793/
https://ncbi.nlm.nih.gov/pubmed/21092862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.09.029
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