An Inducer of VGF Protects Cells against ER Stress-Induced Cell Death and Prolongs Survival in the Mutant SOD1 Animal Models of Familial ALS

Amyotrophic lateral sclerosis (ALS) is the most frequent adult-onset motor neuron disease, and recent evidence has suggested that endoplasmic reticulum (ER) stress signaling is involved in the pathogenesis of ALS. Here we identified a small molecule, SUN N8075, which has a marked protective effect o...

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Autors principals: Shimazawa, Masamitsu, Tanaka, Hirotaka, Ito, Yasushi, Morimoto, Nobutaka, Tsuruma, Kazuhiro, Kadokura, Michinori, Tamura, Shigeki, Inoue, Teruyoshi, Yamada, Mitsunori, Takahashi, Hitoshi, Warita, Hitoshi, Aoki, Masashi, Hara, Hideaki
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000345/
https://ncbi.nlm.nih.gov/pubmed/21151573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015307
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