ENU Mutagenesis Identifies Mice with Morbid Obesity and Severe Hyperinsulinemia Caused by a Novel Mutation in Leptin

BACKGROUND: Obesity is a multifactorial disease that arises from complex interactions between genetic predisposition and environmental factors. Leptin is central to the regulation of energy metabolism and control of body weight in mammals. METHODOLOGY/PRINCIPAL FINDINGS: To better recapitulate the c...

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Главные авторы: Hong, Chen-Jee, Tsai, Pei-Jane, Cheng, Chih-Ya, Chou, Chuan-Kai, Jheng, Huei-Fen, Chuang, You-Chung, Yang, Chia-Ning, Lin, Ya-Tzu, Hsu, Chih-Wei, Cheng, Irene H., Chen, Shiow-Yi, Tsai, Shih-Jen, Liou, Ying-Jay, Tsai, Yau-Sheng
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2010
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000341/
https://ncbi.nlm.nih.gov/pubmed/21151569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015333
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