Heparin Dose Response Is Independent of Preoperative Antithrombin Activity in Patients Undergoing Coronary Artery Bypass Graft Surgery Using Low Heparin Concentrations

BACKGROUND: Unfractionated heparin’s primary mechanism of action is to enhance the enzymatic activity of antithrombin (AT). We hypothesized that there would be a direct association between preoperative AT activity and both heparin dose response (HDR) and heparin sensitivity index (HSI) in patients u...

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Hauptverfasser: Garvin, Sean, Fitzgerald, Daniel, Muehlschlegel, Jochen D., Perry, Tjörvi E., Fox, Amanda A., Shernan, Stanton K., Collard, Charles D., Aranki, Sary, Body, Simon C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999839/
https://ncbi.nlm.nih.gov/pubmed/20142342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0b013e3181ce1ffa
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