The role of central mechanisms in the anti-inflammatory effect of amitriptyline on carrageenan-induced paw edema in rats

OBJECTIVE: The present study was designed to further investigate the effect of amitriptyline, a classical tricyclic antidepressant, on carrageenan-induced paw edema in rats. METHODS: First, amitriptyline was administered intraperitoneally (i.p.) at doses of 20, 40 and 80 mg kg(-1), 30 min before sub...

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Detalhes bibliográficos
Main Authors: Hajhashemi, Valiollah, Sadeghi, Hossein, Minaiyan, Mohsen, Movahedian, Ahmad, Talebi, Ardeshir
Formato: Artigo
Idioma:Inglês
Publicado em: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2010
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999717/
https://ncbi.nlm.nih.gov/pubmed/21243294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/S1807-59322010001100022
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