Distinct hyperpolarizing and relaxant roles for gap junctions and endothelium-derived H(2)O(2) in NO-independent relaxations of rabbit arteries

We have compared the contributions of gap junctional communication and chemical signaling via H(2)O(2) to NO-independent relaxations evoked by the Ca(2+) ionophore A23187 and acetylcholine (ACh) in rabbit ilio-femoral arteries. Immunostaining confirmed the presence of connexins (Cxs) 37 and 40 in th...

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Autori principali: Chaytor, Andrew T., Edwards, David H., Bakker, Linda M., Griffith, Tudor M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2003
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC299961/
https://ncbi.nlm.nih.gov/pubmed/14645719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2435030100
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