Curcumin activates the p38MPAK-HSP25 pathway in vitro but fails to attenuate diabetic nephropathy in DBA2J mice despite urinary clearance documented by HPLC

BACKGROUND: Curcumin has anti-inflammatory, anti-oxidant, and anti-proliferative properties, and depending upon the experimental circumstances, may be pro- or anti-apoptotic. Many of these biological actions could ameliorate diabetic nephropathy. METHODS/DESIGN: Mouse podocytes, cultured in basal or...

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Autori principali: Ma, Jun, Phillips, Lynetta, Wang, Ying, Dai, Tiane, LaPage, Janine, Natarajan, Rama, Adler, Sharon G
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999583/
https://ncbi.nlm.nih.gov/pubmed/21073732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6882-10-67
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