Endothelial Surface Layer Degradation by Chronic Hyaluronidase Infusion Induces Proteinuria in Apolipoprotein E-Deficient Mice

OBJECTIVE: Functional studies show that disruption of endothelial surface layer (ESL) is accompanied by enhanced sensitivity of the vasculature towards atherogenic stimuli. However, relevance of ESL disruption as causal mechanism for vascular dysfunction remains to be demonstrated. We examined if lo...

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Detalhes bibliográficos
Main Authors: Meuwese, Marijn C., Broekhuizen, Lysette N., Kuikhoven, Mayella, Heeneman, Sylvia, Lutgens, Esther, Gijbels, Marion J. J., Nieuwdorp, Max, Peutz, Carine J., Stroes, Erik S. G., Vink, Hans, van den Berg, Bernard M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999536/
https://ncbi.nlm.nih.gov/pubmed/21170388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014262
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