Elevated Pressure Improves the Extraction and Identification of Proteins Recovered from Formalin-Fixed, Paraffin-Embedded Tissue Surrogates

BACKGROUND: Proteomic studies of formalin-fixed paraffin-embedded (FFPE) tissues are frustrated by the inability to extract proteins from archival tissue in a form suitable for analysis by 2-D gel electrophoresis or mass spectrometry. This inability arises from the difficulty of reversing formaldehy...

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Main Authors: Fowler, Carol B., Chesnick, Ingrid E., Moore, Cedric D., O'Leary, Timothy J., Mason, Jeffrey T.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2010
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999528/
https://ncbi.nlm.nih.gov/pubmed/21170380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014253
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