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An adenoviral vector cancer vaccine that delivers a tumor-associated antigen/CD40-ligand fusion protein to dendritic cells

To develop a method to overcome the anergy that exists in tumor hosts to cancer, we have designed an adenoviral vector for the in vivo activation and tumor antigen loading of dendritic cells. This adenoviral vector encodes a fusion protein composed of an amino-terminal tumor-associated antigen fragm...

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Détails bibliographiques
Auteurs principaux: Zhang, Lixin, Tang, Yucheng, Akbulut, Hakan, Zelterman, Daniel, Linton, Phyllis-Jean, Deisseroth, Albert B.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2003
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC299915/
https://ncbi.nlm.nih.gov/pubmed/14645711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2135379100
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