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Inhibition of vascular ectonucleotidase activities by the pro-drugs ticlopidine and clopidogrel favours platelet aggregation

BACKGROUND AND PURPOSE: After conversion to their active forms by the liver, ticlopidine and clopidogrel exert antiplatelet effects through irreversible inhibition of the P2Y(12) receptor. Concentrations of nucleotides such as ADP, the physiological agonist at platelet P2Y(1) and P2Y(12) receptors,...

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Main Authors: Lecka, Joanna, Rana, Manjit Singh, Sévigny, Jean
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Publishing Ltd 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998694/
https://ncbi.nlm.nih.gov/pubmed/20977463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00951.x
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