Retinoic acid stimulates myocardial expansion by induction of hepatic erythropoietin which activates epicardial Igf2

Epicardial signaling and Rxra are required for expansion of the ventricular myocardial compact zone. Here, we examine Raldh2(–/–) and Rxra(–/–) mouse embryos to investigate the role of retinoic acid (RA) signaling in this developmental process. The heart phenotypes of Raldh2 and Rxra mutants are ver...

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Main Authors: Brade, Thomas, Kumar, Sandeep, Cunningham, Thomas J., Chatzi, Christina, Zhao, Xianling, Cavallero, Susana, Li, Peng, Sucov, Henry M., Ruiz-Lozano, Pilar, Duester, Gregg
Formato: Artigo
Idioma:Inglês
Publicado: Company of Biologists 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998168/
https://ncbi.nlm.nih.gov/pubmed/21138976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.054239
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