Induction of Interleukin-6 Expression by Bone Morphogenetic Protein-6 in Macrophages Requires Both SMAD and p38 Signaling Pathways

Unlike the prototype transforming growth factor-β (TGF-β), bone morphogenetic protein-6 (BMP-6) activates macrophages. Here, we report that BMP-6 induces the expression of IL-6 in macrophages. Using overexpression and knockdown experiments, we demonstrate that BMP receptor type II and activin-like k...

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Detalhes bibliográficos
Main Authors: Lee, Geun Taek, Kwon, Seok Joo, Lee, Jae-Ho, Jeon, Seong Soo, Jang, Kee Taek, Choi, Han Yong, Lee, Hyun Moo, Kim, Wun-Jae, Kim, Seong Jin, Kim, Isaac Yi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998138/
https://ncbi.nlm.nih.gov/pubmed/20889504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.103705
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