IGFBP-3 Can Either Inhibit or Enhance EGF-mediated Growth of Breast Epithelial Cells Dependent upon the Presence of Fibronectin

Progression of breast cancer is associated with remodeling of the extracellular matrix, often involving a switch from estrogen dependence to a dependence on EGF receptor (EGFR)/HER-2 and is accompanied by increased expression of the main binding protein for insulin-like growth factors (IGFBP-3). We...

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Detalhes bibliográficos
Main Authors: McIntosh, Jamie, Dennison, Godwin, Holly, Jeff M. P., Jarrett, Caroline, Frankow, Alexandra, Foulstone, Emily J., Winters, Zoe E., Perks, Claire M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998100/
https://ncbi.nlm.nih.gov/pubmed/20851879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.177311
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