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CCR7/CCL21 Migration on Fibronectin Is Mediated by Phospholipase Cγ1 and ERK1/2 in Primary T Lymphocytes

CCR7 binds to its cognate ligand, CCL21, to mediate the migration of circulating naive T lymphocytes to the lymph nodes. T lymphocytes can bind to fibronectin, a constituent of lymph nodes, via their β1 integrins, which is a primary mechanism of T lymphocyte migration; however, the signaling pathway...

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Main Authors: Shannon, Laura A., Calloway, Psachal A., Welch, T. Paul, Vines, Charlotte M.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998076/
https://ncbi.nlm.nih.gov/pubmed/20889506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.152173
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